Estimating covariate-adjusted log hazard ratios in randomized clinical trials using cox proportional hazards models and nonparametric randomization based analysis of covariance.

@article{Saville2013EstimatingCL,
  title={Estimating covariate-adjusted log hazard ratios in randomized clinical trials using cox proportional hazards models and nonparametric randomization based analysis of covariance.},
  author={Benjamin R Saville and Gary G. Koch},
  journal={Journal of biopharmaceutical statistics},
  year={2013},
  volume={23 2},
  pages={477-90}
}
In the context of randomized clinical trials with time-to-event outcomes, estimates of covariate-adjusted log hazard ratios for comparing two treatments are obtained via nonparametric analysis of covariance by forcing the difference in means for covariables to zero. The method avoids the assumption of proportional hazards for each of the covariates, and it… CONTINUE READING