Estimating an individual's true cholesterol level and response to intervention.

@article{Irwig1991EstimatingAI,
  title={Estimating an individual's true cholesterol level and response to intervention.},
  author={Les M. Irwig and Paul G Glasziou and Aaron Wilson and Petra Macaskill},
  journal={JAMA},
  year={1991},
  volume={266 12},
  pages={1678-85}
}
An individual's blood cholesterol measurement may differ from the true level because of short-term biological and technical measurement variability. Using data on the within-individual and population variance of serum cholesterol, we addressed the following clinical concerns: Given a cholesterol measurement, what is the individual's likely true level? The confidence interval for the true level is wide and asymmetrical around extreme measurements because of regression to the mean. Of particular… CONTINUE READING

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