Estimating allele age.

  title={Estimating allele age.},
  author={Montgomery Slatkin and Bruce Rannala},
  journal={Annual review of genomics and human genetics},
The age of an allele can be estimated both from genetic variation among different copies (intra-allelic variation) and from its frequency. Estimates based on intra-allelic variation follow from the exponential decay of linkage disequilibrium because of recombination and mutation. The confidence interval depends both on the uncertainty in recombination and mutation rates and on randomness of the genealogy of chromosomes that carry the allele (the intra-allelic genealogy). Several approximate… 

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