Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.

Abstract

Rates of molecular evolution vary widely between lineages, but quantification of how rates change has proven difficult. Recently proposed estimation procedures have mainly adopted highly parametric approaches that model rate evolution explicitly. In this study, a semiparametric smoothing method is developed using penalized likelihood. A saturated model in… (More)

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@article{Sanderson2002EstimatingAR, title={Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.}, author={Michael J. Sanderson}, journal={Molecular biology and evolution}, year={2002}, volume={19 1}, pages={101-9} }