# Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.

@article{Sanderson2002EstimatingAR, title={Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.}, author={Michael J. Sanderson}, journal={Molecular biology and evolution}, year={2002}, volume={19 1}, pages={ 101-9 } }

Rates of molecular evolution vary widely between lineages, but quantification of how rates change has proven difficult. Recently proposed estimation procedures have mainly adopted highly parametric approaches that model rate evolution explicitly. In this study, a semiparametric smoothing method is developed using penalized likelihood. A saturated model in which every lineage has a separate rate is combined with a roughness penalty that discourages rates from varying too much across a phylogeny… Expand

#### 1,806 Citations

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