Estimating a survival curve with unlinked entry and failure times.

Abstract

In monitoring a clinical trial or other observational study with a survival endpoint, sometimes the numbers of patients entering and dying at each time point are presented, but the connections between them are kept confidential. Hence, the exact time to failure or censoring for each individual is missing. We refer to such a study monitoring table with missing pairing information between the entry and death times as a 'broken' survival data set. In this paper we study the problem of estimating the survival distribution from a broken survival data set. We have developed two methods, likelihood-based estimation and self-consistency estimation, to estimate the survival curve parametrically and empirically, respectively. We use simulations to study the properties of these methods, and illustrate them with data from the STELLAR-3 trial.

Cite this paper

@article{Wu2007EstimatingAS, title={Estimating a survival curve with unlinked entry and failure times.}, author={Yujun Wu and Weichung Joe Shih and Dirk F . Moore}, journal={Statistics in medicine}, year={2007}, volume={26 19}, pages={3624-38} }