Estimating Thermodynamic Stability Relationship of Polymorphs of Sofosbuvir

@inproceedings{Qi2015EstimatingTS,
  title={Estimating Thermodynamic Stability Relationship of Polymorphs of Sofosbuvir},
  author={M. Qi and Minghuang Hong and Yan Liu and En-fu Wang and Fuzheng Ren and Guo-Bin Ren},
  year={2015}
}
The polymorphism of sofosbuvir has been investigated. Three polymorphs have been identified and characterized by X-ray powder diffraction (XRPD) and thermal analysis. Form A and Form B were determined as enantiotropic systems according to the Heat of Fusion Rule. The melting data and isobaric heat capacities of both polymorph have been determined calorimetrically, and the solubility data of each polymorph in water at different temperatures have been determined. With these data, the transition… CONTINUE READING