Estimating Gene Signals From Noisy Microarray Images

@article{Sarder2008EstimatingGS,
  title={Estimating Gene Signals From Noisy Microarray Images},
  author={Pinaki Sarder and Arye Nehorai and P. H. Davis and S. L. Stanley},
  journal={IEEE Transactions on NanoBioscience},
  year={2008},
  volume={7},
  pages={142-153}
}
In oligonucleotide microarray experiments, noise is a challenging problem, as biologists now are studying their organisms not in isolation but in the context of a natural environment. In low photomultiplier tube (PMT) voltage images, weak gene signals and their interactions with the background fluorescence noise are most problematic. In addition, nonspecific sequences bind to array spots intermittently causing inaccurate measurements. Conventional techniques cannot precisely separate the… CONTINUE READING

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