Estimates of optimal vitamin D status

  title={Estimates of optimal vitamin D status},
  author={Bess Dawson-Hughes and Robert Proulx Heaney and Michael F Holick and Paul Lips and Pierre Jean Meunier and Reinhold Vieth},
  journal={Osteoporosis International},
Vitamin D has captured attention as an important determinant of bone health, but there is no common definition of optimal vitamin D status. Herein, we address the question: What is the optimal circulating level of 25-hydroxyvitamin D [25(OH)D] for the skeleton? The opinions of the authors on the minimum level of serum 25(OH)D that is optimal for fracture prevention varied between 50 and 80 nmol/l. However, for five of the six authors, the minimum desirable 25(OH)D concentration clusters between… 
Subclinical vitamin D deficiency.
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes.
Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
Optimal vitamin D status and serum parathyroid hormone concentrations in African American women.
Although a threshold for 25(OH)D can be identified, it should not be used to recommend optimal vitamin D status, and there was no significant difference in rates of bone loss between persons with 25( OH)D concentrations above and below 40 nmol/L.
What is the optimal vitamin D status for health?
  • R. Vieth
  • Medicine
    Progress in biophysics and molecular biology
  • 2006
Impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in oncology
The response to supplementation from suboptimal to optimal levels was greatest in patients with prostate and lung cancer as well as those with baseline levels between 20-32 ng/ml, and the impact of improved serum 25(OH)D levels on patient survival and quality of life needs to be investigated.
High-Dose Vitamin D: Helpful or Harmful?
  • K. Hansen
  • Medicine
    Current rheumatology reports
  • 2011
It is time to question whether serum 25(OH)D levels of 30 ng/mL or greater are necessary for all individuals, after a comprehensive analysis of existing research studies.
Evaluation and correction of low vitamin D status
Clinicians should appreciate that a single 25(OH)D value of “30 ng/mL” may have substantial variability surrounding it, thereby making 25-hydroxyvitamin D levels of approximately 35 to 40 ng/ mL a reasonable therapeutic goal to assure vitamin D adequacy.
25-hydroxyvitamin D measurement, 2009: a review for clinicians.
  • N. Binkley, D. Krueger, G. Lensmeyer
  • Medicine, Biology
    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
  • 2009
Low vitamin D status: definition, prevalence, consequences, and correction.
Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration.
The intake of vitamin D(3) needed to raise serum 25(OH)D to >75 nmol/L must consider the wide variability in the dose-response curve and basal 25( OH)D concentrations.


Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D.
All age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism, and older adults are just as efficient in maintaining 25( OH)D, but they need more vitamin D to produce the higher vitamin D concentrations required to overcome the hyperparathiroidism associated with their diminishing renal function.
Lack of effect of calcium intake on the 25-hydroxyvitamin d response to oral vitamin D3.
In older men and women, the level of calcium intake, within the range of 500-1500 mg/d, does not have an important effect on the rise in serum 25(OH)D that occurs in response to 800 IU (20 microg)/d vitamin D(3).
An International Comparison of Serum 25-Hydroxyvitamin D Measurements
Results show that 25(OH)D values from different laboratories can not be assumed to be comparable unless a careful cross-calibration has been performed, and interlaboratory variation may hamper comparison between results from different populations.
The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects.
It is concluded that a vitamin D3 supplement of 400 IU/day adequately improves vitamin D status in elderly people and increases 1,25-dihydroxyvitamin D concentrations in those with vitamin D deficiency.
Vitamin D and its Major Metabolites: Serum Levels after Graded Oral Dosing in Healthy Men
The quantitative relationships between graded oral dosing with vitamin D3, 25(OH)D3, and 1,25( OH)2D3 for short treatment periods and changes in circulating levels of these substances were determined.
Calcium Absorption Varies within the Reference Range for Serum 25-Hydroxyvitamin D
Calcium absorptive performance at 50 nmol/L was significantly reduced relative to that at a mean 25OHD level of 86 nmol /L, suggesting that individuals with serum 25-hydroxyvitamin D levels at the low end of the current reference ranges may not be getting the full benefit from their calcium intake.
Prevalence of Vitamin D Insufficiency in an Adult Normal Population
The results showed that in French normal adults living in an urban environment with a lack of direct exposure to sunshine, diet failed to provide an adequate amount of vitamin D, and the clinical utility of winter supplementation with low doses ofitamin D was discussed.
Measurement of Vitamin D metabolites: an international perspective on methodology and clinical interpretation
Vitamin D2 is much less effective than vitamin D3 in humans.
Physicians resorting to use of vitamin D(2) should be aware of its markedly lower potency and shorter duration of action relative to vitamin D (3), with the relative potencies for D(3) being 9.5:1.