Estimates of optimal vitamin D status

@article{DawsonHughes2005EstimatesOO,
  title={Estimates of optimal vitamin D status},
  author={Bess Dawson-Hughes and Robert Proulx Heaney and Michael F Holick and Paul Lips and Pierre Jean Meunier and Reinhold Vieth},
  journal={Osteoporosis International},
  year={2005},
  volume={16},
  pages={713-716}
}
Vitamin D has captured attention as an important determinant of bone health, but there is no common definition of optimal vitamin D status. Herein, we address the question: What is the optimal circulating level of 25-hydroxyvitamin D [25(OH)D] for the skeleton? The opinions of the authors on the minimum level of serum 25(OH)D that is optimal for fracture prevention varied between 50 and 80 nmol/l. However, for five of the six authors, the minimum desirable 25(OH)D concentration clusters between… 
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1,906 Citations

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The response to supplementation from suboptimal to optimal levels was greatest in patients with prostate and lung cancer as well as those with baseline levels between 20-32 ng/ml, and the impact of improved serum 25(OH)D levels on patient survival and quality of life needs to be investigated.
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Clinicians should appreciate that a single 25(OH)D value of “30 ng/mL” may have substantial variability surrounding it, thereby making 25-hydroxyvitamin D levels of approximately 35 to 40 ng/ mL a reasonable therapeutic goal to assure vitamin D adequacy.
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Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration.
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The intake of vitamin D(3) needed to raise serum 25(OH)D to >75 nmol/L must consider the wide variability in the dose-response curve and basal 25( OH)D concentrations.
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References

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TLDR
All age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism, and older adults are just as efficient in maintaining 25( OH)D, but they need more vitamin D to produce the higher vitamin D concentrations required to overcome the hyperparathiroidism associated with their diminishing renal function.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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