Estimates of live birth prevalence of children with Down syndrome in the period 1991-2015 in the Netherlands.

  title={Estimates of live birth prevalence of children with Down syndrome in the period 1991-2015 in the Netherlands.},
  author={Gert de Graaf and J. J. Engelen and A C J Gijsbers and Ron Hochstenbach and Mari{\"e}tte J V Hoffer and A J A Kooper and Birgit Sikkema-Raddatz and Malgorzata I Srebniak and Anne-Marie F. van der Kevie-Kersemaekers and Laura J C M van Zutven and Els Voorhoeve},
  journal={Journal of intellectual disability research : JIDR},
  volume={61 5},
BACKGROUND In Western countries, increasing maternal age has led to more pregnancies with a child with Down syndrome (DS). However, prenatal screening programs, diagnostic testing and termination of pregnancy influence the actual DS live birth (LB) prevalence as well. The aim of this study is to examine these factors in the Netherlands for the period 1991-2015. In our study, we establish a baseline for DS LB prevalence before non-invasive prenatal testing will be made available to all pregnant… CONTINUE READING


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