Estimates of cancer potency of 2,3,4,7,8-pentachlorodibenzofuran using both nonlinear and linear approaches.

@article{Simon2008EstimatesOC,
  title={Estimates of cancer potency of 2,3,4,7,8-pentachlorodibenzofuran using both nonlinear and linear approaches.},
  author={Ted W. Simon and Christopher R. Kirman and Lesa L. Aylward and Robert A. Budinsky and Justin Craig Rowlands and Tom F Long},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={106 2},
  pages={519-37}
}
Cancer potency estimates were derived for 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) using data collected from the recently published National Toxicology Program bioassay in female Sprague-Dawley rats. By using a toxicokinetic model for 4-PeCDF, the dose-response relationship for combined liver tumors (hepatocellular adenomas and cholangiocarcinomas) in rats was assessed in terms of lifetime average liver concentration and lifetime average adipose concentration with data from both the lifetime… CONTINUE READING