Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933.

@article{Gondi2010EstimatedRO,
  title={Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933.},
  author={Vinai Gondi and Wolfgang A. Tom{\'e} and James Marsh and Aaron F Struck and A J Ghia and Julius V. Turian and S\oren M\oller Bentzen and John S. Kuo and Deepak Khuntia and Minesh P. Mehta},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2010},
  volume={95 3},
  pages={327-31}
}
BACKGROUND AND PURPOSE RTOG 0933 is a phase II clinical trial of hippocampal avoidance during whole-brain radiotherapy (HA-WBRT) to prevent radiation-induced neurocognitive decline. By quantifying baseline incidence of perihippocampal or hippocampal metastasis, we sought to estimate the risk of developing metastases in the hippocampal avoidance region (the hippocampus plus 5mm margin). MATERIALS/METHODS Patients with < or = 10 brain metastases treated at two separate institutions were… CONTINUE READING

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