Estimate of the genomic mutation rate deleterious to overall fitness in E. coll

@article{Kibota1996EstimateOT,
  title={Estimate of the genomic mutation rate deleterious to overall fitness in E. coll},
  author={Travis T. Kibota and Michael Lynch},
  journal={Nature},
  year={1996},
  volume={381},
  pages={694-696}
}
MUTATIONS are a double-edged sword: they are the ultimate source of genetic variation upon which evolution depends, yet most mutations affecting fitness (viability and reproductive success) appear to be harmful1. Deleterious mutations of small effect can escape natural selection, and should accumulate in small populations2–4. Reduced fitness from deleterious-mutation accumulation may be important in the evolution of sex5–7, mate choice8,9, and diploid life-cycles10, and in the extinction of… CONTINUE READING
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