Estimability and interpretation of vaccine efficacy using frailty mixing models.

@article{Halloran1996EstimabilityAI,
  title={Estimability and interpretation of vaccine efficacy using frailty mixing models.},
  author={M. Elizabeth Halloran and Ira M. Longini and Claudio Jos'e Struchiner},
  journal={American journal of epidemiology},
  year={1996},
  volume={144 1},
  pages={83-97}
}
The authors consider estimability and interpretation of vaccine efficacy based on time to event data, allowing that some of the population might have a very low probability of acquiring disease, and the rest have partial, possibly continuously distributed, susceptibility. The efficacy parameters of interest in the frailty mixing model include the fraction highly unlikely to acquire the infection or disease due to the vaccine, the degree of partial protection in those still susceptible, and the… CONTINUE READING