Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers

@article{Kopen2019EstersOT,
  title={Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers},
  author={Monika Kope{\vc}n{\'a} and Miloslav Machacek and Anna Nov{\'a}{\vc}kov{\'a} and Georgios Paraskevopoulos and Jaroslav Roh and K. V{\'a}vrov{\'a}},
  journal={Scientific Reports},
  year={2019},
  volume={9}
}
  • Monika Kopečná, Miloslav Machacek, +3 authors K. Vávrová
  • Published 2019
  • Chemistry, Medicine
  • Scientific Reports
  • Skin penetration/permeation enhancers are compounds that improve (trans)dermal drug delivery. We designed hybrid terpene-amino acid enhancers by conjugating natural terpenes (citronellol, geraniol, nerol, farnesol, linalool, perillyl alcohol, menthol, borneol, carveol) or cinnamyl alcohol with 6-(dimethylamino)hexanoic acid through a biodegradable ester linker. The compounds were screened for their ability to increase the delivery of theophylline and hydrocortisone through and into human skin… CONTINUE READING
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