The synthesis and results of a pharmacological study of esters of trans and cis isomers of secondary y-amino alcohols of the tetrahydropyran series are described. These esters were synthesized in a search for compounds with anesthetic properties and an explanation was sought for the relationship between the physiological activity of these compounds and their structure and stereochemistry. In the compounds investigated both the acid residue and*the aminomethyl side group were varied. Two series of epimeric esters of benzoic, cinnamic, phenoxyacetic, p-nitroand p-aminobenzoic acids containing diethylamino and hexamethyleneimino groups in the tetrahydropyran cycle were prepared. These groups were chosen because in general they are present in the most active compounds [I].