Esters, amides and substituted derivatives of cinnamic acid: synthesis, antimicrobial activity and QSAR investigations.

@article{Narasimhan2004EstersAA,
  title={Esters, amides and substituted derivatives of cinnamic acid: synthesis, antimicrobial activity and QSAR investigations.},
  author={Balasubramanian Narasimhan and Deepak Belsare and Devayani Pharande and Vishnukant Mourya and Avinash Shridhar Dhake},
  journal={European journal of medicinal chemistry},
  year={2004},
  volume={39 10},
  pages={827-34}
}
A series of esters (I(a-k)), substituted derivatives (II(a-d)) and amides (III(a-q)) of cinnamic acid were synthesized and evaluated as antibacterial and antifungal agents. All the derivatives belonging to the series I, II and III showed antimicrobial activity comparable to the standard. Compounds I(f) and II(c) proved to be the most effective compounds. Quantitative structure-activity relationship (QSAR) investigation with multiple linear regression analysis was applied to find a correlation… CONTINUE READING

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