Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy.

@article{Curcio2005EsterifiedAU,
  title={Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy.},
  author={Christine A. Curcio and Jennifer B. Presley and Goldis Malek and Nancy E Medeiros and Dina V Avery and Howard S. Kruth},
  journal={Experimental eye research},
  year={2005},
  volume={81 6},
  pages={731-41}
}
To address the potential for an outer segment (OS) contribution to the sub-retinal pigment epithelium (RPE) lesions of age-related maculopathy (ARM), we quantified esterified and unesterified cholesterol (EC, UC) with the sterol-specific fluorescent probe filipin in cryosections of ARM eyes. Twenty six eyes from 20 donors were preserved <5 hr after death in 4% paraformaldehyde (n = 16) or 2.5% glutaraldehyde/1% paraformaldehyde (n = 10). Eyes had exudative late ARM (n = 6), geographic atrophy… CONTINUE READING

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