Esterase activity of hemoglobins: a conformational probe for difference between HbA and HbS.

@article{Elbaum1981EsteraseAO,
  title={Esterase activity of hemoglobins: a conformational probe for difference between HbA and HbS.},
  author={Danek Elbaum and Ronald L. Nagel},
  journal={Progress in clinical and biological research},
  year={1981},
  volume={55},
  pages={41-60}
}
(1) We have observed esterase of Hb A and Hb S. The reaction is consistent with general imidazole catalysis. (2) The rate f p-NPA hydrolysis by Hb A and Hb S is significantly different, probably due to subtle conformational alterations involving beta His 2 and/or its micro-environment in the mutant. (3) During this reaction, irreversible modification of Hb occurs, involving lysines (predominantly Lys beta 82).