Esterase activity of hemoglobin. Differences between HB A and HB S.

@article{Elbaum1981EsteraseAO,
  title={Esterase activity of hemoglobin. Differences between HB A and HB S.},
  author={Danek Elbaum and Ronald L. Nagel},
  journal={The Journal of biological chemistry},
  year={1981},
  volume={256 5},
  pages={2280-3}
}
The hydrolysis of p-nitrophenyl acetate (p-NPA) is catalyzed by many proteins. We have observed that oxyhemoglobin A also exhibits esterase activity with a rate intermediate between that of bovine albumin and carbonic anhydrase. Kinetic studies of this reaction revealed that the rate of hydrolysis of p-NPA in the presence of oxy Hb S was approximately 2 times slower than that of oxy Hb A. There is general agreement that the catalytic effect of peptides and proteins on the hydrolysis of p-NPA is… CONTINUE READING