Esterase Inhibition by Grapefruit Juice Flavonoids Leading to a New Drug Interaction

  title={Esterase Inhibition by Grapefruit Juice Flavonoids Leading to a New Drug Interaction},
  author={P. Li and P. Callery and L. Gan and S. Balani},
  journal={Drug Metabolism and Disposition},
  pages={1203 - 1208}
  • P. Li, P. Callery, +1 author S. Balani
  • Published 2007
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • Our previous studies described a newly identified potential of grapefruit juice (GFJ) in mediating pharmacokinetic drug interactions due to its capability of esterase inhibition. The current study identifies the active components in GFJ responsible for its esterase-inhibitory effect. The esterase-inhibitory potential of 10 constitutive flavonoids and furanocoumarins toward p-nitrophenylacetate (PNPA) hydrolysis was investigated. The furanocoumarins bergamottin, 6′,7′-dihydroxybergamottin, and… CONTINUE READING
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