Establishment of two human prostate cancer cell lines derived from a single bone metastasis.

  title={Establishment of two human prostate cancer cell lines derived from a single bone metastasis.},
  author={Nora Navone and Matilde Oliv{\'e} and Mustafa Ozen and Rodney Davis and P. Brunny Troncoso and Shi Ming Tu and Dennis A Johnston and Allan J. Pollack and Sen Pathak and Andrew von Eschenbach and Christopher J. Logothetis},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={3 12 Pt 1},
Human prostate cancer cell lines are particularly difficult to establish, and most existing cell lines do not exhibit features commonly seen in human prostate cancer. Most available models either grow only in vivo as xenografts or are androgen insensitive and fail to express prostate-specific antigen (PSA). The lack of functionally relevant model systems of advanced prostate cancer has limited prostate cancer research and therapy development. Of 30 processed samples derived from patients with… CONTINUE READING


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