Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos.


Placental abnormalities occur frequently in cloned animals. Here, we attempted to isolate trophoblast stem (TS) cells from mouse blastocysts produced by somatic cell nuclear transfer (NT) at the blastocyst stage (NT blastocysts). Despite the predicted deficiency of the trophoblast cell lineage, we succeeded in isolating cell colonies with typical morphology… (More)
DOI: 10.1073/pnas.0908009106


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