Establishment of the Inducible Tet-On System for the Activation of the Silent Trichosetin Gene Cluster in Fusarium fujikuroi

@article{Janevska2017EstablishmentOT,
  title={Establishment of the Inducible Tet-On System for the Activation of the Silent Trichosetin Gene Cluster in Fusarium fujikuroi},
  author={S. Janevska and Birgit Arndt and Leonie Baumann and Lisa Helene Apken and Lucas Maciel Mauriz Marques and Hans-Ulrich Humpf and B. Tudzynski},
  journal={Toxins},
  year={2017},
  volume={9}
}
  • S. Janevska, Birgit Arndt, +4 authors B. Tudzynski
  • Published 2017
  • Medicine, Biology
  • Toxins
  • The PKS-NRPS-derived tetramic acid equisetin and its N-desmethyl derivative trichosetin exhibit remarkable biological activities against a variety of organisms, including plants and bacteria, e.g., Staphylococcus aureus. The equisetin biosynthetic gene cluster was first described in Fusarium heterosporum, a species distantly related to the notorious rice pathogen Fusarium fujikuroi. Here we present the activation and characterization of a homologous, but silent, gene cluster in F. fujikuroi… CONTINUE READING
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