Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation.

@article{Matoba2008EstablishmentOT,
  title={Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation.},
  author={Shogo Matoba and Ryuji Hiramatsu and Masami Kanai-Azuma and Naoki Tsunekawa and Kyoko Harikae and Hayato Kawakami and Masamichi Kurohmaru and Yoshiakira Kanai},
  journal={Developmental biology},
  year={2008},
  volume={324 1},
  pages={76-87}
}
In mouse sex differentiation, SRY promotes Sertoli cell differentiation via SOX9 action, resulting in testis formation. SRY/SOX9 also initiates various testis-specific morphogenic events including glycogenesis in pre-Sertoli cells, suggesting the importance of glucose storage for certain SRY/SOX9-downstream events in gonadal sex determination. However, it remains unclear which cell types and what molecular/cellular events require sex-dimorphic high-energy metabolic rate. Here we show that the… CONTINUE READING

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