Establishment of proliferative tetraploid cells from telomerase-immortalized normal human fibroblasts.


Aneuploidy is observed in the majority of human cancers and is considered to be causally related to carcinogenesis. Although malignant aneuploid cells are suggested to develop from polyploid cells formed in precancerous lesions, the mechanisms of this process remain elusive. This is partly because no experimental model is available where nontransformed… (More)
DOI: 10.1002/gcc.22354

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