Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract

  title={Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract},
  author={H. Damhofer and E. Ebbing and A. Steins and L. Welling and J. Tol and K. Krishnadath and T. van Leusden and M. J. van de Vijver and M. Besselink and O. Busch and M. B. Henegouwen and O. V. van Delden and S. Meijer and F. Dijk and J. P. Medema and H. V. van Laarhoven and M. Bijlsma},
  journal={Journal of Translational Medicine},
  • H. Damhofer, E. Ebbing, +14 authors M. Bijlsma
  • Published 2015
  • Medicine, Biology
  • Journal of Translational Medicine
  • BackgroundThe upper gastrointestinal tract is home to some of most notorious cancers like esophagogastric and pancreatic cancer. Several factors contribute to the lethality of these tumors, but one that stands out for both tumor types is the strong inter- as well as intratumor heterogeneity. Unfortunately, genetic tumor models do not match this heterogeneity, and for esophageal cancer no adequate genetic models exist. To allow for an improved understanding of these diseases, tissue banks with… CONTINUE READING
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