Establishment of new murine embryonic stem cell lines for the generation of mouse models of human genetic diseases.

@article{Sukoyan2002EstablishmentON,
  title={Establishment of new murine embryonic stem cell lines for the generation of mouse models of human genetic diseases.},
  author={M. A. Sukoyan and Alexandre Kerkis and Marco Roberto Bourg de Mello and Irina Kerkis and Jose Antonio Visintin and Lygia da Veiga Pereira},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2002},
  volume={35 5},
  pages={535-42}
}
Embryonic stem cells are totipotent cells derived from the inner cell mass of blastocysts. Recently, the development of appropriate culture conditions for the differentiation of these cells into specific cell types has permitted their use as potential therapeutic agents for several diseases. In addition, manipulation of their genome in vitro allows the creation of animal models of human genetic diseases and for the study of gene function in vivo. We report the establishment of new lines of… CONTINUE READING
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