Establishment of methylation patterns in ES cells

@article{Sabag2014EstablishmentOM,
  title={Establishment of methylation patterns in ES cells},
  author={Ofra Sabag and Ayelet Zamir and Ilana Keshet and Merav Hecht and Guy Ludwig and Amalia Tabib and Joshua Louis Moss and Howard Cedar},
  journal={Nature Structural &Molecular Biology},
  year={2014},
  volume={21},
  pages={110-112}
}
After erasure in the early animal embryo, a new bimodal DNA methylation pattern is regenerated at implantation. We have identified a demethylation pathway in mouse embryonic cells that uses hydroxymethylation (Tet1), deamination (Aid), glycosylation (Mbd4) and excision repair (Gadd45a) genes. Surprisingly, this demethylation system is not necessary for generating the overall bimodal methylation pattern but does appear to be involved in resetting methylation patterns during somatic-cell… CONTINUE READING

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Annotating the genome by DNA methylation.

  • The International journal of developmental biology
  • 2017
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DNA demethylation pathways: Additional players and regulators.

  • BioEssays : news and reviews in molecular, cellular and developmental biology
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DNA repair and erasure of 5-methylcytosine in vertebrates.

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