Establishment of lethal inhalational infection with Francisella tularensis (tularaemia) in the common marmoset (Callithrix jacchus).

@article{Nelson2009EstablishmentOL,
  title={Establishment of lethal inhalational infection with Francisella tularensis (tularaemia) in the common marmoset (Callithrix jacchus).},
  author={Michelle R. Nelson and Mark Stephen Lever and Victoria L. Savage and Francisco J Salguero and Peter C. Pearce and Daniel J. Stevens and Andrew J. H. Simpson},
  journal={International journal of experimental pathology},
  year={2009},
  volume={90 2},
  pages={109-18}
}
Susceptibility and lethality studies of inhalational tularaemia were undertaken using the common marmoset (Callithrix jacchus) to determine its suitability as a non-human primate model. Pairs of marmosets were exposed to varying challenge doses of Francisella tularensis by the airborne route and monitored for up to 14 days postchallenge (p.c.). Lethal infection was achieved following a retained dose of less than 10 bacterial colony-forming units (CFU). However, precise LD(50) determination was… CONTINUE READING

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