Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2.

  title={Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2.},
  author={Nan Papili Gao and Peter White and Klaus H. Kaestner},
  journal={Developmental cell},
  volume={16 4},
We demonstrate that conditional ablation of the homeobox transcription factor Cdx2 from early endoderm results in the replacement of the posterior intestinal epithelium with keratinocytes, a dramatic cell fate conversion caused by ectopic activation of the foregut/esophageal differentiation program. This anterior homeotic transformation of the intestine was first apparent in the early embryonic Cdx2-deficient gut by a caudal extension of the expression domains of several key foregut endoderm… CONTINUE READING
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Molecular mechanisms of development of the gastrointestinal tract

  • D. J. Roberts
  • Dev. Dyn. 219, 109–120.
  • 2000
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