Establishment of immortalized mesenchymal stromal cells with red fluorescence protein expression for in vivo transplantation and tracing in the rat model with traumatic brain injury.

@article{Hung2010EstablishmentOI,
  title={Establishment of immortalized mesenchymal stromal cells with red fluorescence protein expression for in vivo transplantation and tracing in the rat model with traumatic brain injury.},
  author={Chi-Jen Hung and Chao-Ling Yao and F Cheng and Mei-ling Wu and Tzu-Hao Wang and Shiaw-Min Hwang},
  journal={Cytotherapy},
  year={2010},
  volume={12 4},
  pages={
          455-65
        }
}
BACKGROUND AIMS Human mesenchymal stromal cells (hMSC) play a crucial role in tissue engineering and regenerative medicine, and have important clinical potential for cell therapy. However, many hMSC studies have been restricted by limited cell numbers and difficult detection in vivo. To expand the lifespan, hMSC are usually immortalized by virus-mediated gene transfer. However, these genetically modified cells easily lose critical phenotypes and stable genotypes because of insertional… CONTINUE READING

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Feasibility of a stem cell therapy for intervertebral disc degeneration.

The spine journal : official journal of the North American Spine Society • 2008

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