Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.

@article{Silva2003EstablishmentOH,
  title={Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.},
  author={Jos{\'e} Guilherme Nogueira da Silva and Winifred Mak and Ilona Zvetkova and Ruth Appanah and Tatyana B. Nesterova and Zoe Webster and Antoine H F M Peters and Thomas Jenuwein and Arie P. Otte and Neil Brockdorff},
  journal={Developmental cell},
  year={2003},
  volume={4 4},
  pages={481-95}
}
Previous studies have implicated the Eed-Enx1 Polycomb group complex in the maintenance of imprinted X inactivation in the trophectoderm lineage in mouse. Here we show that recruitment of Eed-Enx1 to the inactive X chromosome (Xi) also occurs in random X inactivation in the embryo proper. Localization of Eed-Enx1 complexes to Xi occurs very early, at the onset of Xist expression, but then disappears as differentiation and development progress. This transient localization correlates with the… CONTINUE READING
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