Establishment of gonadotropin-responsive murine leydig tumor cell line

@article{Rebois1982EstablishmentOG,
  title={Establishment of gonadotropin-responsive murine leydig tumor cell line},
  author={Raymond V. Rebois},
  journal={The Journal of Cell Biology},
  year={1982},
  volume={94},
  pages={70 - 76}
}
Several clonal Leydig tumor cell lines have been established by adapting the transplantable Leydig tumor, M548OP, to culture. One of these cell line, MLTC-1, has been characterized with regard to the gonadotropin-responsive adenylate cyclase system. The binding of 125I-labeled human chorionic gonadotropin (hCG) was blocked by excess unlabeled hCG and lutropin (LH) but not by follitropin, thyrotropin, or insulin, indicating the presence of specific receptors for hCG and LH. Based on the specific… CONTINUE READING

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