Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.

@article{Liu2010EstablishmentOE,
  title={Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.},
  author={Weimin Liu and Kavita Tundwal and Qiaoling Liang and Nicholas P Goplen and Sadee Rozario and Nayeem Quayum and Magdalena G{\'o}rska and Sally Wenzel and Silvana Balzar and Rafeul Alam},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 7},
  pages={
          1783-99
        }
}
Our objective was to establish an experimental model of a self-sustained and bistable extracellular signal-regulated kinase 1/2 (ERK1/2) signaling process. A single stimulation of cells with cytokines causes rapid ERK1/2 activation, which returns to baseline in 4 h. Repeated stimulation leads to sustained activation of ERK1/2 but not Jun N-terminal protein kinase (JNK), p38, or STAT6. The ERK1/2 activation lasts for 3 to 7 days and depends upon a positive-feedback mechanism involving Sprouty 2… CONTINUE READING

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