Establishment of chronic intravenous drug self-administration in the C57BL/6J mouse.

@article{Carney1991EstablishmentOC,
  title={Establishment of chronic intravenous drug self-administration in the C57BL/6J mouse.},
  author={John M. Carney and R W Landrum and M. S. Cheng and Thomas W. Seale},
  journal={Neuroreport},
  year={1991},
  volume={2 8},
  pages={477-80}
}
A wide variety of drugs that have significant human abuse potential have been demonstrated to function as positive reinforcers in animals. The present study was designed to characterize a new mouse model of chronic intravenous drug self-administration. Adult male C57BL/6J mice, implanted with external jugular infusion catheters, were given access to response-contingent injections. They did not initiate responding for saline delivery, whereas the C57BL/6J mice initiated morphine, cocaine… CONTINUE READING

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