Establishment of cell-cell junctions depends on the oligomeric states of VE-cadherin.

Abstract

Specifically expressed at intercellular adherens junctions of endothelial cells, VE-cadherin is a receptor that exhibits particular self-association properties. Indeed, in vitro studies demonstrated that the extracellular part of VE-cadherin elaborates Ca(++)-dependent hexameric structures. We hypothesized that this assembly could be at the basis of a new… (More)
DOI: 10.1093/jb/mvn035

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