Establishment of anti-human neuroblastoma-selective isotype-switch variants.

@article{dUscio1992EstablishmentOA,
  title={Establishment of anti-human neuroblastoma-selective isotype-switch variants.},
  author={C d'Uscio and Kurt Blaser},
  journal={Journal of immunological methods},
  year={1992},
  volume={146 1},
  pages={63-70}
}
Isotype-switch variants of monoclonal antibodies occur spontaneously at low frequency in hybridoma cultures. We have established gamma 2b variants from the gamma 1/kappa antibody-secreting murine hybridoma CE7 and gamma 2a-secreting variants from a selected CE7 gamma 2b clone. The CE7 antibodies selectively recognize a cell surface glycoprotein of 185 kDa… CONTINUE READING