Establishment of an adult mouse model for direct evaluation of the efficacy of vaccines against Vibrio cholerae.

@article{Nygren2009EstablishmentOA,
  title={Establishment of an adult mouse model for direct evaluation of the efficacy of vaccines against Vibrio cholerae.},
  author={Erik Nygren and B Li and Jan Holmgren and Stephen R. Attridge},
  journal={Infection and immunity},
  year={2009},
  volume={77 8},
  pages={3475-84}
}
We describe here a new animal model that offers the prospect of using conventional adult mice for direct evaluation of the protective potential of new cholera vaccines. Pretreatment of adult mice with oral streptomycin allowed intestinal colonization by streptomycin-resistant Vibrio cholerae strains of either the O1 or the O139 serogroup. Bacteria were recovered in greatest numbers from the cecum and large intestine, but recoveries from all regions of the gut correlated significantly with… CONTINUE READING
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