Establishment of an HLA-A*0201 human papillomavirus type 16 tumor model to determine the efficacy of vaccination strategies in HLA-A*0201 transgenic mice.

@article{Eiben2002EstablishmentOA,
  title={Establishment of an HLA-A*0201 human papillomavirus type 16 tumor model to determine the efficacy of vaccination strategies in HLA-A*0201 transgenic mice.},
  author={Gretchen Lyons Eiben and Markwin P. Velders and Hans Schreiber and Maria Cristina Cassetti and Jeffrey K. Pullen and Larry R. Smith and W. Martin Kast},
  journal={Cancer research},
  year={2002},
  volume={62 20},
  pages={5792-9}
}
With the increasing generation of new cancer vaccine strategies, there is also an increasing demand for preclinical models that can carefully predict the efficacy of these vaccines in humans. However, the only tumor models available to study vaccines against human papillomavirus (HPV) 16 have been developed in C57BL/6 mice. To test the HLA-restricted capabilities of vaccination strategies, it is important to establish a tumor model in HLA-A*0201 transgenic mice. By transfecting heart lung… CONTINUE READING