Establishment of a schizophrenic animal model through chronic administration of MK-801 in infancy and social isolation in childhood.

Abstract

BACKGROUND Although an increasing amount of evidence supports a "two-hit" hypothesis for the neurodevelopmental model of schizophrenia, there has been no development in animal models to test this hypothesis. METHODS An animal model was established by chronic administration of 0.1, 0.3, and 0.5mg/kg MK-801 in P7-P21 rats followed by four weeks of social… (More)
DOI: 10.1016/j.infbeh.2017.01.003

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