Establishment of a quiescent herpes simplex virus type 1 infection in neurally-differentiated PC12 cells.

@article{Danaher1999EstablishmentOA,
  title={Establishment of a quiescent herpes simplex virus type 1 infection in neurally-differentiated PC12 cells.},
  author={Robert J. Danaher and Robert J. K. Jacob and Craig S. Miller},
  journal={Journal of neurovirology},
  year={1999},
  volume={5 3},
  pages={
          258-67
        }
}
Rat pheochromocytoma (PC12) cells differentiated with nerve growth factor (Nd-PC12) were used to investigate the establishment of a non-productive herpes simplex virus type 1 (HSV-1) infection that is reversible. The results of this work are as follows: (i) Nd-PC12 cultures could be maintained as long term (>7 weeks) non-dividing cultures only when plated on collagen-coated dishes in the absence of serum; (ii) Infection of Nd-PC12 with HSV-1 strains KOS and 17 in the transient presence of… CONTINUE READING

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