Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions

  title={Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions},
  author={Jin Young Joo and Hyun Woo Choi and Min Jung Kim and Holm Zaehres and Natalia Tapia and Martin Stehling and Koo Sung Jung and Jeong Tae and Hans R. Sch{\"o}ler},
  booktitle={Scientific reports},
Several mouse pluripotent stem cell types have been established either from mouse blastocysts and epiblasts. Among these, embryonic stem cells (ESCs) are considered to represent a "naïve", epiblast stem cells (EpiSCs) a "primed" pluripotent state. Although EpiSCs form derivatives of all three germ layers during in vitro differentiation, they rarely incorporate into the inner cell mass of blastocysts and rarely contribute to chimera formation following blastocyst injection. Here we successfully… CONTINUE READING
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history, mechanisms, and applications

  • M. Stadtfeld, Hochedlinger, K. Induced pluripotency
  • Genes & Development 24, 2239–2263
  • 2010

subpopulations represent mouse embryos of distinct pregastrulation stages

  • Y. Mayshar
  • 2010

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