Establishment of a novel human B-CLL-like xenograft model in nude mouse.

  title={Establishment of a novel human B-CLL-like xenograft model in nude mouse.},
  author={S{\'e}verine Loisel and Karine Le Ster and Isabelle Quintin-Rou{\'e} and Jacques-Olivier Pers and Anne Bordron and Pierre Youinou and Christian Berthou},
  journal={Leukemia research},
  volume={29 11},
We have developed a novel murine model for B-CLL by engrafting human prolymphocytic leukemia (PLL) or B-CLL cell line cells (JVM-3 and MEC-2 cell lines, respectively) into nude mice. Not only treatment of the mice was a prerequisite for the success of the graft, but also for the first time, females appeared to accept the cells more easily than males. Surprisingly, tumoral murine models for B-CLL could be established with PLL cells but not with B-CLL cells. JVM-3 cells were efficiently… CONTINUE READING

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