Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats

  title={Establishment of a novel dwarf rat strain: cartilage calcification
insufficient (CCI) rats},
  author={Masami Tanaka and Minoru Watanabe and Izuru Yokomi and Naoki Matsumoto and Katsuko Sudo and Hitoshi Satoh and Tsuneo Igarashi and Azusa Seki and Hitoshi Amano and Kiyoshi Ohura and Kakei Ryu and Shunichi Shibata and Motohiko Nagayama and Jun-ichi Tanuma},
  booktitle={Experimental animals},
Rats with dwarfism accompanied by skeletal abnormalities, such as shortness of the limbs, tail, and body (dwarf rats), emerged in a Jcl-derived Sprague-Dawley rat colony maintained at the Institute for Animal Experimentation, St. Marianna University Graduate School of Medicine. Since the dwarfism was assumed to be due to a genetic mutation based on its frequency, we bred the dwarf rats and investigated their characteristics in order to identify the causative factors of their phenotypes and… CONTINUE READING


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