Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

@article{Greene1976EstablishmentOA,
  title={Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.},
  author={L. Greene and A. Tischler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1976},
  volume={73 7},
  pages={
          2424-8
        }
}
  • L. Greene, A. Tischler
  • Published 1976
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • A single cell clonal line which responds reversibly to nerve growth factor (NGF) has been established from a transplantable rat adrenal pheochromocytoma. This line, designated PC12, has a homogeneous and near-diploid chromosome number of 40. By 1 week's exposure to NGF, PC12 cells cease to multiply and begin to extend branching varicose processes similar to those produced by sympathetic neurons in primary cell culture. By several weeks of exposure to NGF, the PC12 processes reach 500-1000 mum… CONTINUE READING
    Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium
    260
    NERVE GROWTH FACTOR-INDUCED INCREASE IN SAXITOXIN BINDING TO RAT PC 12 PHEOCHROMOCYTOMA CELLS
    2