Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function.

@article{Sano2010EstablishmentOA,
  title={Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function.},
  author={Yasuteru Sano and Fumitaka Shimizu and Masaaki Abe and Toshihiko Maeda and Yoko Kashiwamura and Sumio Ohtsuki and Tetsuya Terasaki and Masuo Obinata and Koji Kajiwara and Masami Fujii and Michiyasu Suzuki and Takashi Kanda},
  journal={Journal of cellular physiology},
  year={2010},
  volume={225 2},
  pages={519-28}
}
The breakdown of the blood-brain barrier (BBB) has been considered to be a key step in the disease process of a number of neurological disorders such as cerebral ischemia and Alzheimer's disease. Many in vitro BBB models derived from animal tissues have been established to elucidate the mechanism of BBB insufficiency. However, only a few human immortalized in vitro BBB models have been reported. In the present study, a temperature-sensitive SV40-T antigen was introduced to immortalize cells… CONTINUE READING

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