Establishment of a mouse model for human rhinovirus infection.

  title={Establishment of a mouse model for human rhinovirus infection.},
  author={F. H. Yin and N B Lomax},
  journal={The Journal of general virology},
  volume={67 ( Pt 11)},
We describe here a mouse model for rhinovirus infection using a variant of human rhinovirus type 2 (HRV2/H) which replicated 50- to 300-fold in the lungs of BALB/c mice. The variant virus differed only marginally from HRV2/H according to various biochemical parameters. Use of a photosensitive inoculum and pretreatment of the animals with actinomycin D were necessary for detection of reproducible and significant levels of virus replication. This mouse model of rhinovirus infection is the first… CONTINUE READING


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