Establishment of a mouse model for human rhinovirus infection.

@article{Yin1986EstablishmentOA,
  title={Establishment of a mouse model for human rhinovirus infection.},
  author={F. H. Yin and N B Lomax},
  journal={The Journal of general virology},
  year={1986},
  volume={67 ( Pt 11)},
  pages={2335-40}
}
We describe here a mouse model for rhinovirus infection using a variant of human rhinovirus type 2 (HRV2/H) which replicated 50- to 300-fold in the lungs of BALB/c mice. The variant virus differed only marginally from HRV2/H according to various biochemical parameters. Use of a photosensitive inoculum and pretreatment of the animals with actinomycin D were necessary for detection of reproducible and significant levels of virus replication. This mouse model of rhinovirus infection is the first… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…