Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues.

@article{Sun1996EstablishmentOA,
  title={Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues.},
  author={F. X. Sun and Zao You Tang and Kei Lui and Sheng-long Ye and Qung Xue and Dakuan Gao and Zeng-chen Ma},
  journal={International journal of cancer},
  year={1996},
  volume={66 2},
  pages={239-43}
}
A highly metastatic LCI-D20 model of human hepatocellular carcinoma (HCC) was obtained via orthotopic implantation of a histologically preserved metastatic tumour selected from 1 of 30 surgical specimens, and had been maintained for 18 passages in nude mice. All mice with transplanted tumours exhibited 100% transplantability and metastatic ability, as well as various manifestations reminiscent of tumour behaviour in HCC patients. These included: local growth, regional invasion, spontaneous… CONTINUE READING

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