Establishment of a lymphoblastoid cell line, SD-1, expressing the p190 bcr-abl chimaeric protein.

@article{Dhut1991EstablishmentOA,
  title={Establishment of a lymphoblastoid cell line, SD-1, expressing the p190 bcr-abl chimaeric protein.},
  author={Susheela Dhut and Barbara Gibbons and Tracy Chaplin and Bryan D. Young},
  journal={Leukemia},
  year={1991},
  volume={5 1},
  pages={49-55}
}
A lymphoblastoid cell line (SD-1) has been established by Epstein-Barr virus immortalisation of Philadelphia chromosome positive acute lymphoblastic leukaemia (ALL) cells. Using newly derived anti-bcr monoclonal and anti-abl polyclonal antibodies it was demonstrated that both the original leukaemic cells and the derived cell line expressed the p190 form of the bcr-abl protein found in a proportion of cases of Philadelphia chromosome positive ALL. Interestingly, the leukaemia and the derived… CONTINUE READING

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