Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris.

@article{Inoue2007EstablishmentOA,
  title={Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris.},
  author={Kenji Inoue and Akira Sugiyama and Patrick C. Reid and Yukio Ito and Katsumi Miyauchi and Sei Mukai and Mina Sagara and Kyoko Miyamoto and Hirokazu Satoh and Isao Kohno and T. Kurata and Hiroshi Ota and Alberto Mantovani and Takao Hamakubo and Hiroyuki Daida and Tatsuhiko Kodama},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 1},
  pages={161-7}
}
OBJECTIVE Plasma pentraxin 3 (PTX3) levels are increased in patients with acute myocardial infarction, yet its involvement in unstable angina pectoris (UAP) remains unclear. To critically evaluate the role of PTX3 in UAP, a sensitive and precise measurement of PTX3 concentration is needed. METHODS AND RESULTS We established a high sensitive plasma ELISA assay system for the detection of PTX3 using monoclonal antibodies. The lower limit of detection of our ELISA was 0.1 ng/mL, sensitivity far… CONTINUE READING

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